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Tue 3 Mar - Wed 4 Mar 2020
10:00 - 13:00

Venue: Todd-Hamied

Provided by: Department of Chemistry


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Chemistry: DD10 Process Chemistry Workshop
New

Tue 3 Mar - Wed 4 Mar 2020

Description

In this session, Dr. Mukund S. Chorghade will discuss the pivotal role played by Process Chemistry / Route Selection in the progress of a drug from conception to commercialization. The medicinal chemistry routes for synthesis are usually low yielding and are fraught with capricious reactions, cryogenic temperatures, tedious chromatography and problems in scale-up to multi-kilo and multi-ton levels. Considerable research efforts have to be expended in developing novel, cost efficacious and scalable processes and seamlessly transferring these technologies to manufacturing operations. These principles will be exemplified by process development case studies on a variety of pharmaceutical moieties such as anti-epileptic and an anti-asthma drugs. We were able to also discover a large number of New Chemical Entities by our new “Process Chemistry Driven Medicinal Chemistry”

We will exemplify advances in proprietary in vitro green chemistry-based technology, mimicking in vivo metabolism of several chemical entities used in pharmaceuticals, cosmetics, and agrochemicals. Our catalysts enable prediction of metabolism patterns with soft-spot analysis Metabolites are implicated in adverse drug reactions and are the subject of intense scrutiny in drug R&D. Present-day processes involving animal studies are expensive, labor-intensive and chemically inconclusive. Our catalysts (azamacrocycles) are sterically protected and electronically activated, providing speed, stability and scalability. We predict structures of metabolites, prepare them on a large scale by oxidation, and elucidate chemical structures. Comprehensive safety evaluation enables researchers to conduct more complete in vitro metabolism studies, confirm structure and generate quantitative measures of toxicity.

Target audience
  • Chemistry postgraduates
  • Further details regarding eligibility criteria are available
  • If you are from outside the Department of Chemistry, please wait to be collected from reception
Sessions

Number of sessions: 2

# Date Time Venue Trainer
1 Tue 3 Mar   10:00 - 13:00 10:00 - 13:00 Todd-Hamied Dr Mukund Chorghade
2 Wed 4 Mar   10:00 - 13:00 10:00 - 13:00 Todd-Hamied Dr Mukund Chorghade
Duration
  • Two sessions of two hours
Related courses
Theme
Drug Discovery

Booking / availability