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Tue 4 Jun 2019
09:30 - 12:00

Venue: Bioinformatics Training Room, Craik-Marshall Building, Downing Site

Provided by: Bioinformatics


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COSMIC: Integrating and interpreting the world’s knowledge of somatic mutations in cancer
PrerequisitesNew

Tue 4 Jun 2019

Description

COSMIC, the Catalogue of Somatic Mutations in Cancer, is the world’s largest and most comprehensive expert manually curated resource for exploring the impact of somatic mutations in human cancer. Based at the Wellcome Sanger Institute and available publicly at https://cancer.sanger.ac.uk/cosmic, the latest release includes almost 6 million coding mutations across 1.4 million samples from over 26,000 papers. COSMIC captures the full spectrum of genomic data relating to somatic mutations, so in addition to coding mutations, gene fusions, non-coding mutations, copy-number variants, methylation and drug resistance mutations are included.

This course will use the live COSMIC website and tools to show you how to access and explore this information, seeking to identify genetic causes and targets in all human cancers.

The training room is located on the first floor and there is currently no wheelchair or level access available to this level.

Please note that if you are not eligible for a University of Cambridge Raven account you will need to book by linking here.

Target audience
  • This course is aimed at scientists, clinicians and informaticians interested in cancer genetics, encompassing all aspects of academic research, data integration and visualisation, and industrial investigations into diagnostic and pharmaceutical design across all human cancers.
  • Graduate students, Postdocs and Staff members from the University of Cambridge, Affiliated Institutions and other external Institutions or individuals
  • Please be aware that these courses are only free for registered University of Cambridge students. All other participants will be charged a registration fee in some form. Registration fees and further details regarding the charging policy are available here.
  • Further details regarding eligibility criteria are available here
Sessions

Number of sessions: 1

# Date Time Venue Trainers
1 Tue 4 Jun   09:30 - 12:00 09:30 - 12:00 Bioinformatics Training Room, Craik-Marshall Building, Downing Site map Simon Forbes,  Claire Rye
Objectives

After this course you should be able to:

  • Understand the range of genetic drivers of cancer.
  • Access large quantities of genetic variant data across all human cancers.
  • Identify trends in this information via the COSMIC analytical website.
  • Explore cancer variation alongside all functional genomic annotations using the COSMIC genome browser.
  • Discuss how cancer genetics is evolving, and how COSMIC might support your future research.
Aims

During this course you will learn about:

  • Somatic cancer genetics; the range of genetic events and disease types underlying this disease.
  • How to access over 25 million mutations from several genetic mechanisms observed across more than 3000 disease descriptions standardised into one database.
  • How to explore trends in this information to identify genetic causes of disease, using the COSMIC website & tools.
Format

Presentations, demonstrations and practicals

Timetable

Time Topics
09:30-10:15 Introduction to COSMIC, what it does, how & why
10:15-10:30 Specialised resources within COSMIC
10:30-11:30 Online tutorial – how to get the most out of the website
11:30-11:45 Data structure and how to access and download the data
11:45-12:00 Q&A
Registration Fees
  • Free for registered University of Cambridge students
  • £ 50/day for all University of Cambridge staff, including postdocs, temporary visitors (students and researchers) and participants from Affiliated Institutions. Please note that these charges are recovered by us at the Institutional level
  • It remains the participant's responsibility to acquire prior approval from the relevant group leader, line manager or budget holder to attend the course. It is requested that people booking only do so with the agreement of the relevant party as costs will be charged back to your Lab Head or Group Supervisor.
  • £ 50/day for all other academic participants from external Institutions and charitable organizations. These charges must be paid at registration
  • £ 100/day for all Industry participants. These charges must be paid at registration
  • Further details regarding the charging policy are available here
Duration

0.5

Frequency

Once a year

Theme
Databases and Services

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